Killbox is a neat little utility that makes file deletion a breeze. Very often when I am cleaning a computer of Malware, I will eventually identify a malicious application and attempt to remove it. However, if the program is in memory then no matter what I do I won't be able to delete the file. Enter Killbox.
When you find one of these persistent files/folders, tell killbox where it is and how to kill it; worst case scenario, killbox will remove the file after a reboot.
My favorite part about it, is that Killbox is a stand-alone executable. So carrying it around on a thumb drive is a breeze.